Granulation is the process of making granules from a powder, which produces granular material. The granulation is applied in several technical processes in the chemical and pharmaceutical manufacturing.
Granulation is a technique where powder particles bind to each other, resulting in homogeneous and larger granules. It is a mechanism of bonding particles together by forming bonds, and this bonding is formed by compression or by using a binding agent.
Granules are prepared in two ways: dry granulation or wet granulation. Dry granulation involves a dry mixing, slug-de-slug, and roller compaction processes and wet granulation includes aqueous (using granulation liquid) and non-aqueous granulation.
- The major application of granulation is that it is broadly used in the pharmaceutical industry to manufacture solid dosage forms such as tablets and capsule granules.
- The major applications of wet granulation are that it is used to improve compressibility, electrostatic properties, flow, and the stability of solid dosage forms.
- The major applications of dry granulation are that it is used when the drug does not compress well after wet granulation, and it is also suitable for moisture sensitive drugs (APIs).
- Granulation is essential to enhance the powder flow and mechanical properties of the tablet.
- Granulation is used to improve the appearance of the product.
- It is also used to improve fluidity, the compressibility of the material, and decrease dusting.
Commonly asked questions o granulation are as follows.
What are the two types of granulation?
Granulation technique is generally classified into two types, namely dry granulation, and wet granulation.
What is the advantage of using dry granulation?
The advantage of dry granulation is that there is no moisture content in the formulation, so it is suitable for moisture-sensitive compounds.
What is the advantage of using wet granulation?
Wet granulation makes granules more spherical than powder, so it has better flow properties and is suitable for a wide variety of dissolution rates.
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