Disintegration is a physical process related to the mechanical fragmentation of small particles of a tablet or granulate particle. It is used as a quality control test and has many advantages, let's check it out.
The disintegration test is performed to determine the disintegration time taken by the solid dosage form by which the quality of the tablet and capsule can measure. Disintegration is broadly applied in the pharmaceutical industry. It is an essential test performed to check the disintegration ability of tablets and capsules, as per pharmacopoeia standards such as IP, USP, and BP.
Advantages of the disintegration test:
- It determines the disintegration time, which is significant for the development of the oral disintegrating tablet.
- According to pharmacopoeia standards such as IP, USP, and BP, it checks the quality of pharmaceutical products.
- Multi samples at a time can be tested using dissolution media.
- This gives important safety data on the bioavailability of the drug (API) in the body without using in vivo methods.
- No expert required, easy to operate, and robust.
- The disintegration test takes less time and it is less complex than the dissolution test.
- The pH of the buffer of the medium can be easily changed than the dissolution testing.
- It can be easily automated.
The disintegration test apparatus has one or two baskets assemblies with separate timers and motors, a beaker, an external probe for beaker temperature, timer and temperature display, and one water bath connected to the programmable temperature controller.
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