When the system successfully to maintain constant levels of drugs in the target tissue or blood, it is called a controlled-release system. The controlled release dosage form is that which delivers the medicaments at a predetermined rate for a prescribed period. The controlled release drug delivery system uses drug encapsulating devices that allow the release of active pharmaceutical ingredients (API) at controlled rates over long periods; it can be from days to months. This type of dosage form offers several advantages over traditional methods of drug delivery, check out some of the advantages and disadvantages of controlled release dosage forms.
Advantages of controlled release dosage forms:
You may also like this
Advantages of controlled release dosage forms:
- The major advantage of a controlled release drug delivery system is that it allows the release of drugs at controlled rates over long periods; it can be from days to months.
- The total dose of a drug is lower than other drug delivery systems.
- It reduces fluctuations in drug levels in the blood.
- The controlled release dosage form provides a more uniform drug effect.
- It does not harm the gastrointestinal tract, because the dose of the drug is low.
- The controlled release dosage form is more convenient for both caregiver and patient.
- It drugs give prolonged action and reduces the frequent dosage.
- This reduces local side effects, by decreasing the total amount of the drug.
- In it, there is no problem with the unpleasant taste and odor of medicines.
- The major disadvantage of a controlled release drug delivery system is that the system needs to be physically implanted and removed from the sites.
- High molecular weight compounds are difficult to deliver.
- Some factors can affect the release rate of the drug.
- If the system fails, the possible toxicity cost per unit increases.
- Doctors need to convince or educate the patient about this before the use of a controlled release dosage form.
- Not all drugs are appropriate for the formulation in the controlled release dosage form.
- There is no flexibility in dose adjustment, as it has a fixed dosage form.
- Dose dumping can be possible in case of a poor formulation strategy or device.
- The patient may discomfort with the delivery device and the higher cost of systems than conventional pharmaceutical formulations.
- It delays the onset of drug action.
Commonly asked questions on dosage forms are as follows.
What is the disadvantage of using modified release dosage forms?
The major disadvantage of modified release dosage forms is that it provides long action of the drug therefore, its side effects may last longer than shorter-acting, immediate release dosage forms. Modified release dosage forms are generally available in the form of tablets, capsules, and caplets.
How many types of modified release dosage forms?
Modified release dosage forms have two types, extended-release dosage form and delayed-release dosage form, prolonged-release, sustained-release, and controlled release are the different terminologies also used in the modified release.
What is the disadvantage of buccal or sublingual administration?
It is not suitable for those drugs that need to be absorbed gradually into the system.
What is the advantage of effervescent tablets?
The major advantage of effervescent tablets is that it provides the instant effect of the drug and easy to take for patients, particularly for children and elderly.
What is the advantage of the enteric coating?
The enteric-coated dosage form is used to release the active pharmaceutical ingredient (API) in the small intestine and avoid the release of medication in the stomach.
You may also like this
No comments:
Post a Comment