The extended-release dosage form is designed to deliver medicaments to the body where it should be absorbed, simplifying the scheduled dosing and ensuring that the drug concentration is maintained at a suitable time interval. Extended-release dosages are a commonly used technique for delivering drugs into the bloodstream and are achieved by incorporating coated granules or beads into capsules or tablets. Sustained-release, controlled-release, and long-acting drug products are some examples of extended-release dosage forms. There are some advantages to providing drugs administered by this process, but it also has some disadvantages, let’s check it.
Advantages of extended-release dosage forms:
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Advantages of extended-release dosage forms:
- The major advantage of the extended-release dosage form is that it provides long action of the drug and reduces the frequency of dosing.
- The extended-release dosage forms often reduce the requirement of night-time doses that are helpful to both caregiver and patient.
- There is no need to take tablets and capsules repeatedly, which is very beneficial for children and old people.
- It can be used to maintain drug levels by controlling the rate of drug release.
- Extended-release dosage forms may improve patient compliance.
- The rate and extent of absorption of medicaments can be modified.
- There is no problem with the unpleasant taste and odor of the drugs as it is already coated with granules.
- It reduces side effects, reduces the amount of time required for health treatment, and improves medical benefits.
- They are easy to carry, transport, and don't require special storage conditions.
- Formulation of extended-release can be possible in solid dosage forms but is very difficult to formulate in liquid and semi-solid dosage forms.
- It delivers the medicaments at the prescribed rate as per the needs of the body throughout the treatment of the patient.
- The major disadvantage of the extended-release dosage form is its high cost as it has a higher manufacturing cost than other dosage forms.
- Another major disadvantage of extended-release dosage forms is that side effects can remain much longer than an immediate release, short-acting product.
- Failure of the technique may result in the risk of the sudden and total release of the drug.
- It is not useful whenever partial doses are needed because they need to be taken intact, not divide into parts.
- Splitting or divided into parts can cause its release property to be lost.
- The combination of multiple drugs and excipients or ingredients complicates it to formulate.
- Extended-release formulations may cause a slower onset of action.
- Not all drugs are compatible with the formulation of extended-release dosage forms.
- The release rate can change by various factors such as food and fasting.
- The release rate can vary from one dose to another dose.
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