Monday, September 10, 2018

Applications of Buffer Solution in Pharmacy

The buffer is a combination of an acid-base aqueous solution adjusted to an accurate pH value. The buffer is used to maintain a specific pH of the solution; it is used in the analysis and manufacture of various manufacturing processes such as food processing, electroplating, manufacture of medicines especially injection, ear drops, eye droplets, suspension, dissolution of tablets, etc.
Here are mentioned some applications of buffer solution are as follows. 
Improving Purity: 
Proteins are purified depends on the fact that amphoteric compounds are slightly soluble at their isoelectric point. For example, insulin precipitates from the aqueous solution in the pH range of 5 to 6. This technique is used for insulin purification. 
Increased Stability: 
Because of hydrolysis, many compounds are unstable in aqueous solutions. These solutions can be stabilized by regulating the pH. For example, the stability of vitamins is within a narrow range of pH only. 
Enhanced solubility: 
If the pH of the solution is not properly maintained, then the drug dissolution can precipitate. This principle applies in the dosage forms manufacturing, and some pharmaceutical ingredients and drugs dissolve only at specific pH, hence, it is necessary to maintain the right pH of the solution. 
Optimizing Biological Activity: 
Enzymes contain most activity only on certain pH values. For example, at pH 1.5, there is a maximum activity of pepsin.




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