It is most important to see compounds related to stereochemistry, these compounds have the same chemical structure, but there is a different spatial orientation. These types of compounds can be considered as impurities in the active pharmaceutical ingredients. The chirality can be observed in a molecule containing one or more tetrahedral carbon by four dissimilar substances. Chiral molecules can also be due to many different reasons and should be the factor in any impurities evaluation. Chiral molecules are often called enantiomers. The enantiomers optical isomers with similar chemical structure, but are the dissimilar spatial arrangement.
It is important that they do not ignore them because a compound d-isomer may have dissimilar toxicological or pharmacological activity, so, the unwanted optical isomer is considered to be active pharmaceutical ingredients chiral impurity. Also, it is significant to consider that the number of chiral impurities increases with the rising number of asymmetric carbon atoms in the molecule.
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