The pharmaceuticals degradation reactions occur in the chemical in nature and at limited rates. Temperature, Solvent, radiation energy, pH of the medium, the presence of a catalyst, and the concentration of reactants are the factors which are having an effect on these reactions. The sequence of reaction is the attribute in the way in which rate of reaction depends on reactant concentration. To make certainly enhanced stability prophecy, it is significant to recognize the limitations of experimental heat obtained by activation values are critical. To calculate the degradation rates at each pH value for dissimilar temperatures, the heat of activation should be obtained for all the bimolecular rate constants concerned in the rate pH profile.
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