The Dry granulation method is widely used in dry granulation conditions where the effectual drug dose for direct compression is very high, and the drug is responsive to moisture, heat, which prevents wet granulation. It is also called compression grain. This includes compaction of components through tablet presses or specially featured equipment, after milling and screening prior to final compression into a tablet. For this cause, this is recognized as the slugging method. This method is largely done with a or specially featured instrument called Roller Compactor, Which can be milled or screened in granulation appropriate for compression in the tablet.
The following are the steps involved in the dry granulation process.
- Weigh and mixing of the ingredients
- Screening
- Pre-compression into the soft tablets
- Crushing into granules
- Screening
- Adding lubricating agents
- The final punch of tablets
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