Modified release dosage form is a mechanism that delivers a medication after its administration or for a long time or to a specific target site in the body, it provides significant advantages over traditional dosage forms.
The oral solid dosage form is the most preferred route of administration by patients for many medications since they offer many advantages over the single unit dose form (e.g. Capsules, caplets, tablets, or pellets). Modified-release dosages and their variants are the mechanisms used in tablets and capsules that dissolve active pharmaceutical ingredients (API) to release in a slow or controlled manner and to stabilize in the bloodstream.
Modified release dosage forms are drug delivery systems that, based on the formulation and product design, provide drug release in a modified form (delayed or extended) different from traditional dosage forms. Therefore, the modified release dosage form is ideal and has many applications in pharmacy, such as the decrease in the frequency of doses, reduction in drug blood level fluctuations, decrease in the incidence of adverse side effects, and enhanced patient compliance.
Advantages of various types of modified release dosage forms:
- The major advantage of modified release dosage forms is that to reach clinical objectives, it can control the rates and site of drug release, which cannot be attained by traditional dosage forms.
- The extended-release dosage form allows for a reduction of at least twofold in the dosage frequency, as compared to the immediate-release or conventional dosage form.
- The major advantage of the sustained release dosage form is that releases the medication at a predetermined rate to provide long-term therapeutic effects by continuously releasing the drug.
- By using a targeted release dosage form, it is possible to deliver the drug to the patient in a way that increases the concentration of the drug in specific parts of the body.
- In a single dose, both immediate release and delayed release of the drug can be possible using the repeat-action tablet.
- Delayed-release dosage forms such as tablets or capsules are usually enteric-coated that are designed to pass through the stomach, which subsequently releases their medication within the intestinal tract.
- A small amount of the drug is required to produce the desired effect.
- It can reduce the gastric irritation and side effects of the drug.
- Unpleasant taste, odor, and color of the drug can be masked using a coating, which is convenient for children and elderly patients who have difficulty swallowing.
- As compared with other types of dosage forms it is possible to enhance the bioavailability.
- This improves patient convenience and compliance.
- Providing Minimum fluctuation in circulation drug level can provide a more uniform effect on the patients.
Commonly asked questions on dosage forms are as follows.
What are the different types of modified release dosage forms?
Sustained-release dosage forms, extended-release dosage forms, prolonged-action dosage forms, controlled-release dosage forms, repeat-action dosage forms, targeted-release dosage forms, and delayed-release dosage forms are some of the types of modified release drug delivery systems.
What is the major disadvantage of modified release dosage forms?
The major disadvantage of the modified release dosage form is that its side effects last longer because it retains more time in the body compared to the short-acting, immediate release dosage form.
What are the types of tablet dosage form?
Buccal tablets, chewable tablets, compressed tablets, dispensing tablets, effervescent tablets, enteric-coated tablets, film-coated tablets, gelatin-coated tablets, hypodermic tablets, multiple-compressed tablets, rectal tablet, sublingual tablets, sugar-coated tablets, sustained action tablets, and vaginal tablets.
You may also like this
No comments:
Post a Comment