Saturday, April 4, 2020

Advantages and disadvantages of adsorption chromatography

The adsorption chromatography is a form of chromatography and it is the most widely used method in the form of column chromatography, gas-solid chromatography, and thin-layer chromatography. Adsorption chromatography consists of a stationary phase (fine solid partitioned) and a mobile phase (solvent or a mixture of solvents). The analyte differently interacts with the stationary phase because every analyte has a different affinity towards the adsorbent. Therefore, the separation of molecules occurs at different retention times.
The advantages of adsorption chromatography are as follows.
  • It has a wide range of mobile phases for the separation of compounds.
  • Adsorption chromatography is an important method to separate many components that are not separated by other techniques.
  • The complex sample mixtures can be easily separated by this method.
  • Very few types of apparatus or types of equipment are required for isolation.
The disadvantages of adsorption chromatography are as follows.
  • Obtained results from some methods of adsorption chromatography are complex to reproduce.
  • This can cause catalytic variations.
  • Some solutes take retention time to separate this is a major disadvantage of adsorption chromatography.
  • It is more complicated and costly when make automation.


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