Monday, August 13, 2018

What equation describes the rate of drug dissolution from tablets

Dissolution is the step of rate determination for the poorly aqueous soluble drug and hydrophobic molecules.
As per the USP a drug product is believed to quickly dissolve when no less than the 85% of the claim amount of the molecule dissolve within the 30 minutes, by using USP apparatus-I on 100 RPM or 50 RPM for USP apparatus-II, into a 900 ml volume or less in all of the media, like 0.1 n HCl, a pH 4.5 buffer, pH6.8 buffer.

Dissolution rate equation

dw/dt= ks (Csat-Csol)

Where

dw/ dt = are dissolution rate

k = a dissolution constant

 S = surface area of the solid

C sat = the concentration of a saturated solution

C sol = the concentration at any given time

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