Advantages and disadvantages of partition chromatography

Partition chromatography is a kind of chromatography, in that sample components are distributed in two liquids due to variation in the partition coefficient. In this technique, both stationary and mobile phases are in the same phase and in which the molecules are separated. Thus the analytes are distributed at any phage. "Partition" is basic principle that is used in several chromatographic methods such as high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), gas chromatography (GC), and paper chromatography. Gas-liquid chromatography and liquid-liquid chromatography are the types of partition chromatography
The advantages of partition chromatography are as follows.

• The advantages of partition chromatography consist of an easy-to-operate and economical method for separation.

• The partition chromatography technique can isolate both organic and inorganic compounds.

• It saves time because in a short duration it separates compounds.

• It provides high efficiency.

• This technique provides accurate results.

• Selectivity is better in partition chromatography because a mobile phase can be simply changed.

The disadvantages of partition chromatography are as follows.

• The high volume of the mobile phase is sometimes required for separation

• Data cannot be stored long in certain types of partition chromatography.

• Automation has made it more difficult and costly.

• In gas-liquid chromatography, only volatile compounds can be separated.

• It is possible to separate only soluble analytes of sample mixtures.

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