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Saturday, April 4, 2020

Advantages and disadvantages of chiral chromatography

Chiral chromatography is a type of chromatographic technique used to separate the enantiomers of a chiral compound. It can use to determine the ratio of the enantiomers found in a sample or to separate different enantiomers. It consists of a mobile phase, either liquid or gas passing over a chiral stationary phase in a cylindrical column. A sample component injected into the mobile phase and as per their different affinities for the chiral stationary phase, they separated. The chiral chromatography is used when some analytes have a chiral center and they not isolate by the reversed-phase chromatography and normal phase chromatography.
The advantages of chiral chromatography are as follows.
  • The majorities of inorganic molecules are chiral and are analyzed by this method.
  • Board ranges of the chiral column are available.
  • This chromatographic method provides fast and accurate results.
  • You can get different selectivity’s from the chiral phases.
The disadvantages of chiral chromatography are as follows.
  • It is used only to separate chiral compounds. This is the major disadvantage of chiral chromatography.
  • we need to be an expert to handle the system.
  • The major disadvantage of chiral chromatography is the need for pure chiral substances and their relative slowness.
  • Several chiral additives are expensive, and must often be synthesized.

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