Wet granulation is the most commonly used method in many pharmaceuticals and other industries, for the production of compressed tablets. In this process, by the wet massing of the drug (API) and excipients using granulation fluid the granules are produced.
There is a solvent used which should be volatile so that it can be removed by drying and be non-toxic. Specific liquids contain water, isopropanol, and ethanol in singular or in combination. The granular liquid can be used unaccompanied or, more usually, A dissolved adhesive as a solvent, which is used to make sure the particle adhesion after drying of the granule.
The following are the steps involved in the Wet granulation process.
- Weighing and mixing the ingredients
- Preparing for wet mass
- Screening of the damp mass into granules
- Drying for removing the solvents
- Screening
- Adding lubricating agents
- Compression
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