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Friday, March 17, 2023

Preparation of NaCl solution

Learn how to make different concentrations of molar and normal sodium chloride solutions, which are needed for many applications such as research, practical, pharmaceutical, chemical laboratory, and industries, etc.


Sodium chloride, also known as salt, is an ionic substance having the chemical formula NaCl with a sodium and chloride ions ratio of 1:1. It is a crystalline solid with an fcc structure, and it contains four ions of each Na+ and Cl-.

The reaction between hydrochloric acid (HCl) and sodium hydroxide (NaOH) produces NaCl. In this reaction, both the acid and the base are strong. It can be found in the oceans and seawater, as well as in rock salt.

It is used in medicine (saline solution), fire extinguishers, the textile industry, and the paper industry as well as to produce sodium carbonate, and also used in water softening, etc.

Generally, a solid form of sodium chloride (NaCl) in different-sized packs is supplied in the market by vendors in the form of white/colorless crystalline or cubic crystals that are usually about 98-100% pure.


Requirements of glassware, chemicals, and apparatus:

Digital balance, beaker, pipette, pipette bulb, volumetric flask, measuring cylinder, glass rod, funnel, distilled water, AR/LR grade sodium chloride (NaCl), etc.

Calculation method:

In this case, we must determine the mass of sodium chloride (NaCl) required to make 1 molar solution of NaCl as well as the volume of the solution. We must use the molarity formula, which is,
Molarity= Moles of solute/Volume of solution

Step-by-step complete answer:
We must first determine the moles of NaCl. The solution is 1 L in volume and has a molarity of 1 M.
So, moles of NaCl can be calculated as,
Moles of NaCl=Molarity × Volume of solution= 1L
Moles of NaCl= 1 M ×1L=1 mol
Therefore, the mole of NaCl in the solution is 1 mol.
The mass of NaCl now is calculated using the number of moles of NaCl.
Number of moles= Mass/Molar mass
The mole of NaCl is 1 mol, and its molar mass is 58.44 g/mol.
1=Mass/58.44g/mol
Mass of NaCl=58.44 g
Therefore, to make a 1 M solution of NaCl, we need to dissolve 58.44 g of sodium chloride in 1 liter of distilled water.

Note:
Because the valency of NaCl is 1, the molarity and normality of the solution are the same.

How to prepare 0.02M NaCl solution?

Weigh accurately 01.17 g of sodium chloride and dissolve it in 500 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 1000 ml with distilled water, and properly mix it.

How to prepare a 0.05M NaCl solution?

Weigh accurately 02.92 gm of sodium chloride and dissolve it in 250 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 1000 ml with distilled water, and properly mix it.

How do you make a 0.1M sodium chloride solution?

Weigh accurately 05.84 gm of sodium chloride and dissolve it in 500 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 1000 ml with distilled water, and properly mix it.

How to prepare 0.2N NaCl solution?

Weigh accurately 11.69 gm of sodium chloride and dissolve it in 500 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 1000 ml with distilled water, and properly mix it.

How to prepare 0.25M sodium chloride solution?

Weigh accurately 14.61 gm of NaCl and dissolve in 700 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 01 liter with distilled water, and properly mix it.

How to prepare 0.5N NaCl solution?

Weigh accurately 29.22 gm of NaCl and dissolve in 400 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 01 liter with distilled water, and properly mix it.

How to prepare 1N NaCl solution?

Weigh accurately 58.44 gm of sodium chloride and dissolve it in 500 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 1000 ml with distilled water, and properly mix it.

How to prepare a 2N solution of pentahydrate sodium chloride?

Weigh accurately 29.22 gm of NaCl and dissolve in 200 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 250 ml with distilled water, and properly mix it.

How do you make a 1% solution of NaCl?

Weigh accurately 01.00 gm of sodium chloride and dissolve it in 50 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 100 ml with distilled water, and properly mix it.

How do you make a 5% sodium chloride solution?

Weigh accurately 05.00 gm of NaCl and dissolve it in 50 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 100 ml with distilled water, and properly mix it.

How to prepare 10% sodium chloride solution?

Weigh accurately 10.00 gm of NaCl and dissolve it in 50 ml of distilled water in a volumetric flask. Once it has completely dissolved, make up the volume to 100 ml with distilled water, and properly mix it.

How to prepare a 100 ppm solution of NaCl?

In a volumetric flask, dissolve 10 mg of sodium chloride in 100 ml of distilled water to produce a 100 ppm stock solution.

How do you make a 1 ppm solution of sodium chloride?

Take 0.1 ml (100 microliters) from 100 ppm stock solution of sodium chloride and dilute it to 10 ml, the resulting solution has a concentration of 1 ppm.

How do you make a 10 ppm solution of sodium chloride?

Take 01 ml from 100 ppm stock solution of sodium chloride and dilute it to 10 ml, the resulting solution has a concentration of 1 ppm.

Preparation of NaCl solution


PRECAUTIONS:
  • When working with chemicals, avoid contact with skin, eyes, clothing, ingestion, and inhalation.
  • NaCl is hygroscopic in nature it should be stored in a tightly closed container.
  • Stir a little amount of sodium chloride into a large volume of water at a time, and then dilute the solution.
  • When making sodium chloride solutions, it is recommended that always use distilled water.
  • Wear protective gloves, clothing, eye protection, and face protection.
  • Wash your hands/skin thoroughly after handling.
  • Solutions are highly alkaline and corrosive. Contact can cause serious skin and eye irritation. Therefore should be handled with care, follow laboratory safety measures (SOP/Procedure), and please use extreme caution when preparing the solution concentrations.

References:
  1. Indian Pharmacopoeia : 1996
  2. Wikipedia contributors. (2023, March 11). Sodium chloride. In Wikipedia, The Free Encyclopedia. Available Here: 
  3. sWhat Is the Difference between Molarity and Normality? Westlab, Available Here:
  4. Laboratory Solution Preparation, Available Here:

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